講座題目：小分子探針在藥物傳遞及生物成像中應用 Small molecule-based drug delivery system and its bioimagings

報 告 人：Kim Jong Seung（教授,，韓國科學院院士）

時 　 間：2019年9月10日(周二)10:00

地 　 點：中關村校區(qū)求是樓425/426學術交流室

主辦單位：研究生院,、材料學院

報名方式：登錄北京理工大學微信企業(yè)號---第二課堂---課程報名中選擇“【百家大講堂】第233期：小分子探針在藥物傳遞及生物成像中應用 ”

【主講人簡介】

Kim Jong Seung教授，韓國高麗大學化學系教授,，韓國科學院院士,，主要研究興趣包括靶向藥物釋放系統(tǒng)的開發(fā),，生物熒光成像與老年癡呆綜合癥的檢測與治療方法研究，主客體化學及杯芳烴化學等領域,，近年來在J.Am. Chem. Soc., Angew. Chem. Int. Ed, Chem. Science, Chem. Rev., Chem. Soc. Rev.等國際著名期刊上發(fā)表研究論文及綜述430篇左右,，總引用次數(shù)達31500次，個人H-index：93,，獲得授權專利約70項,。

【講座信息】

  基因組學、蛋白質組學和生物信息學的發(fā)展對抗癌藥物的開發(fā)具有重要的指導意義,，可以減少藥物濫用,，增加安全和特異性的藥物治療。治療診斷學將治療與診斷相結合,，是一種具有腫瘤選擇性靶向,、毒性降低、副作用小等優(yōu)點的藥物治療方法,。磁性顆粒,、介孔二氧化硅、各種聚合物納米顆粒的治療診斷學被廣泛認可,，具有重要的臨床意義,。目前，基于共軛熒光化合物在癌癥治療和診斷中受到了廣泛的關注,。這些結構相對簡單,、生物相容性好。在這次演講中,，我將介紹在課題組最新的共軛化合物的治療診斷學的應用及用于腫瘤治療和診斷,。

The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibit improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tool in theranostic is to collect the information of diseased state before and after specific treatment. Magnetic particle, mesoporous silica, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible. In this talk, the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence undertaken in my lab will be given.